The Missouri Division was formed in Fayette, Missouri, January 12, 1898, at the Court House in the Circuit Court room. Representatives either in person or by proxy were present from the 4 Chapters of the State (Margaret A. E. McLure Chapter #119, Kansas City Chapter #149, Liberty Chapter #147 and Richmond Grey's Chapter #148). In addition to the delegates, almost the full membership of the local Chapter and a number of Confederate Veterans and Sons of Veterans were present. Mrs. R.E. Wilson was the first President. The Division reported at the 1898 General Convention that the seven Chapters are "largely interested in caring for cemeteries in various parts of the State and in erecting monuments to the memory of our fallen heroes".

The Margaret A. E. McLure Chapter #119 was chartered on July 1, 1897, the first Chapter of the United Daughters of the Confederacy in Missouri.

Saint Louis, Missouri has the honor of being the first organization of women bearing the name "Daughters of the Confederacy". It was organized in January 27, 1891.

The State had two organizations, the Daughters of the Confederacy and the United Daughters of the Confederacy until 1902 when the two groups united into one group, the United Daughters of the Confederacy. Later, the national organization, formed in 1894, took the name and became the National Daughters of the Confederacy. In 1895, it became United Daughters of the Confederacy.

In 1890, the ex-Confederate Association of Missouri purchased a farm near Higginsville for a home for the Confederate veterans. Financial difficulties soon arose. At the call of Mrs. A. C. Cassidy, ninety-seven women met January 27, 1891, in the Southern Hotel at Saint Louis and formed an auxiliary to the association, adopting the name "Daughters of the Confederacy", the first group to use the name for a Confederate women's organization. Mrs. Margaret A. E. McLure was the first president. The early organization, with festivals and other moneymaking schemes, soon raised over $23,000. It paid for the main and central buildings of the Confederate home and furnished several cottages.

Today there are thirteen Chapters in the State of Missouri and four Chapters of the Children of the Confederacy.