| 1663
| Carolina Charter granted by King Charles II.
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| 1729
| North Carolina becomes a royal colony.
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| 1776
| Declaration of Independence.
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| 1776
| Adoption of the first state constitution.
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| 1790
| North Carolina cedes its western territory to the federal government; formation of Tennessee Territory.
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| 1833
| Yancey County formed from Burke and Buncombe Counties.
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| 1841
| Caldwell County formed from Burke and Wilkes Counties.
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| 1842
| McDowell County formed from Rutherford and Burke Counties.
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| 1849
| Watauga County formed from Ashe, Wilkes, Caldwell and Yancey Counties.
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| 1861
| North Carolina secedes from the Union (20 May).
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| 1861
| Mitchell County formed from Yancey, Watauga, Caldwell, Burke, and McDowell Counties.
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| 1868
| Adoption of the second state constitution; North Carolina readmitted to the Union.
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| 1870
| The population of Mitchell County is 4,705.
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| 1880
| The population of Mitchell County is 9,438.
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| 1900
| The population of Mitchell County is 15,221.
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| 1903
| Creation of the North Carolina Historical Commission (now the Division of Archives and History).
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| 1907
| Some records lost in move to new courthouse.
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| 1910
| The population of Mitchell County is 17,245.
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| 1911
| Avery County formed from Mitchell, Watauga, and Caldwell Counties.
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| 1917-18
| United States involvement in World War I.
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| 1918
| Worldwide influenza pandemic.
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| 1920
| The population of Mitchell County is 11,278.
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| 1930
| The population of Mitchell County is 13,962.
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| 1935
| Beginning of Blue Ridge Parkway construction under the Civilian Conservation Corps.
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| 1937-42
| Works Progress Administration - North Carolina Historical Records Comission surveys of pre-1914 graves in Mitchell County.
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| 1940
| The population of Mitchell County is 15,980.
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| 1941-45
| United States involvement in World War II.
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| 1942
| Civilian Conservation Corps abolished.
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| 1950
| The population of Mitchell County is 15,143.
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| 1960
| The population of Mitchell County is 13,906.
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| 1970
| The population of Mitchell County is 13,447.
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| 1970
| Adoption of the third state constitution.
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| 1971
| Founding of Mayland Technical Institute.
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| 1979
| Mayland Technical Institute becomes Mayland Technical College (3 December).
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| 1980
| The population of Mitchell County is 14,428.
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| 1987
| Blue Ridge Parkway completed with the final work on the Linn Cove Viaduct.
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| 1988
| Mayland Technical College becomes Mayland Community College (1 January).
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| 1990
| The population of Mitchell County is 14,433.
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| 2000
| The population of Mitchell County is 15,687.
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