| Business Name | Business Type |
|
| Gamble's Mill * | Grist Mill | 1823 |
| Eli Wilson's Mill | Saw Mill | 1824-1825 |
| Duncan & Post Store * | General Store | 1828-1832 |
| New England Hotel * | Hotel | 1828 - 1832 |
| Brown & Mickey | General Store | 1839 |
| Sutter Furniture Company | Cabinet Making | 1844 |
| Ott Brothers - (F. A. & F. B. Ott) | Tannery & Harness Shop | ca. 1857 |
| The Shelby Pioneer | Newspaper | 1858 - 1859 |
| City Mills | Milling | ca. 1860 |
| Farmer's Exchange | Bank | 1868 - 1869 |
| Shreffler Carriage Works | Wagons & Carriages | 1872 |
| First National Bank | Bank | 1872 |
| The Shelby Bakery Co. | Bakery | 1872 - 1876 |
| Shelby Mill Co. | Milling | 1876 |
| Mann & Steele | Hardware Merchants | 1876 |
| Skiles & Skiles | Lawyers | 1878 |
| C.H. Moyer & Son | Mens Clothing / Tailor | ca. 1879 |
| Mutual Plate Glass | Insurance | 1880 |
| Seltzer & Steele | Merchants | 1879 - 1880 |
| Shelby Steel Tube Works | Steel Tubing | 1890 |
| Bazaar | Groceries | ca. 1894 |
| Shelby Cycle Company | Bicycles | Sept. 1895 |
| Shelby Water Co | Utility | Feb.10, 1896 |
| Shelby Electric Company | Electric Lamps | 1897 |
| Green & Co. | Drug & Book Store | Dec. 1897 |
| Shelby Plow & Foundry Co. | Shelby Burch Plow, iron castings | ca. 1897 |
| Rib Manufacturing Co. | Hulls Patent Umbrella Rib | ca. 1897 |
| Sheets Printing Co. | Business Printing | ca. 1898 |
| Shelby Motor Car Co. (Beardsley and Hubbs Company) | Automobiles | 1900-1901 |
| The Shelby Spring Hinge Company | Door & Cabinet Hardware | 1900-1901 |
| Machine Shop | 1904 | |
| Clouse and Disbro | Millinery Shop | 1905 |
| The Shelby Printing/Salesbook Co. | Carbon/Book Printing | 1905 |
| Armstrong, Rauch, & Trimble | Retail Hardware | 1906 |
| Autocall Company | Signaling Equip. | 1908 |
| Roethlisberger Transfer Company | Trucking Company | 1913 |
| Shelby Tractor & Truck Company | Assembled Tractors & Trucks | 1918 |
| Shelby Gum Co. | Bubble gum, chewing gum | 1924 |
| Carton Service | Manufacture folding cartons | 1926 |
