| Name of Grantee | Acres | Local Description | Year | Book | Page |
| Salts, Edward | 250 | Short Hill Mt. | 1781 | 2 | 576 |
| Sargent, Sargeant, Searjeant, Surgeant | |||||
| Schoppert, Jacob | 1a1r22p | Opequon Creek | 1848 | 2 | 267 |
| Scott, Geroge | 434 | Back Creek | 1792 | 1 | 138 |
| Seaman, Jonah | 31 | Wts. Opequon | 1780 | 2 | 526 |
| Seamon, Phebe | 217 | Opequon Creek | 1799 | 1 | 224 |
| Seamon, Phebe | 54 | Opequon Creek | 1799 | 1 | 225 |
| Seamon, Phebe | 720 | Opequon Creek | 1803 | 1 | 314 |
| Sharff, See Sheriff | |||||
| Sharff, Jacob & John | 1,405 | Meadow Branch | 1835 | 1 | 479 |
| Sharff, John & Jacob | 202a10p | Third Hill Mt. | 1835 | 1 | 433 |
| Sharp, Thomas | 332 | Back Creek | 1780 | 2 | 534 |
| Shearer, Archibald | 336 | Wts. Potomac | 1778 | 2 | 454 |
| Sheriff See Sharff | |||||
| Sheriff, John | 317 | Sillwater Branch | 1788 | 1 | 20 |
| Sheriff, John Sr. | 127 | Sleepy Creek | 1788 | 1 | 33 |
| Shields, John (Shield) | 201 | Back Creek | 1777 | 1 | 576 |
| Shields, John | 128 | Adj. John Champion | 1789 | 1 | 39 |
| Shields, John | 118 | Gilliland's Run | 1777 | 1 | 574 |
| Shields, William | 18 1/2 | Tilehauzey Branch | 1791 | 1 | 107 |
| Shields, William | 22 | Adj. Robt. Jackson | 1791 | 1 | 111 |
| Shields, William | 16a2r | Back Creek | 1802 | 1 | 272 |
| Shields, William | 11a2r19p | Back Creek | 1829 | 1 | 436 |
| Shimp, Mahala J. | 73 | Tilehouze's Branch | 1848 | 2 | 269 |
| Shockey, Jacob | 100 | Middle Fork | 1799 | 1 | 253 |
| Shockey, Jacob | 69 | Middle Fork | 1807 | 1 | 346 |
| Shockey, John | 262 | Middle Fork | 1775 | 1 | 526 |
| Silar See Sylar | |||||
| Silar, Jacob | 199 | Back Creek | 1804 | 1 | 332 |
| Siler, Jacob | 126 | Back Creek | 1780 | 2 | 540 |
| Silkwood, Solomon | 220 | Back Creek | 1788 | 1 | 32 |
| Small, John | 18 | Opequon Cr. | 1804 | 1 | 327 |
| Small, John M. et al | 50 | North Mountain | 1847 | 2 | 265 |
| Smith, James | 9 | Sleepy Creek | 1819 | 1 | 398 |
| Smith, John | 212 | Sleepy Creek | 1776 | 1 | 551 |
| Smith, John et al | 15 | Tilhance's Branch | 1819 | 1 | 404 |
| Smith, John et al | 15 | Tilhance's Branch | 1819 | 1 | 405 |
| Smith, Mary & James | 400 | Mill Creek | 1795 | 1 | 169 |
| Smith, William | 127 | Stoney Lick Run | 1776 | 1 | 543 |
| Smoot, Edward | 265 | White Gap | 1789 | 1 | 48 |
| Smyth, Alexander | 209 | Cherry Branch | 1801 | 1 | 464 |
| Smythi, Isaac & John | 285 | Stony Lick Run | 1804 | 1 | 329 |
| Snider, See Snyder | |||||
| Snider, Jacob | 54 | Back Creek | 1787 | 1 | 7 |
| Snider, Jacob | 44 | Back Creek | 1789 | 1 | 38 |
| Snider, Jacob | 140 | Back Creek | 1773 | 1 | 493 |
| Snively, Henry | 400 | Meadow Branch | 1792 | 1 | 127 |
| Snively, Henry | 400 | Glady Meadows | 1776 | 1 | 549 |
| Snodgrass, Robert | 19a33p | Adj. James Winning | 1799 | 1 | 221 |
| Snodgrass, Robert | 290 | Back Creek | 1774 | 1 | 513 |
| Snodgrass, Robert | 46 | Back Creek | 1774 | 1 | 516 |
| Snodgrass, Robert | 300 | Elk Hill | 1774 | 1 | 518 |
| Snodgrass, Robert Jr. | 85 | Back Creek | 1802 | 1 | 293 |
| Snodgrass, Robert Jr. | 50 | Back Creek | 1820 | 1 | 414 |
| Snodgrass, Robert V. | 2a3r16p | Adj. H.G. Kitchen | 1849 | 2 | 272 |
| Snodgrass, Robert V | 10 | Back Creek | 1849 | 2 | 273 |
| Snodgrass, Robert V | 210 | Rock Gap Run | 1819 | 1 | 400 |
| Snodgrass, Stephen | 30 | Back Creek | 1799 | 1 | 227 |
| Snodgrass, Stephen | 86 | Back Creek | 1816 | 1 | 389 |
| Snodgrass, Stephen | 48 | Wts. Potomac | 1818 | 1 | 390 |
| Snodgrass, Stephen | 472 1/2 | Amberson Branch | 1798 | 1 | 459 |
| Snyder, See Snider | |||||
| Snyder, Abraham | 107 | North Mountain | 1830 | 1 | 438 |
| Snyder, Gasper | 234a2r22p | Back Creek | 1800 | 1 | 256 |
| Snyder, William | 22 | North Mountain | 1854 | 2 | 287 |
| Soder, John R. | 150 | Wts. Potomac | 1789 | 1 | 78 |
| Southood, See Southwood | |||||
| Southood, Edward | 102 | Adj. A. Throckmorton | 1793 | 1 | 158 |
| Southood, Edward | 20 | Wts. Opequon Cr. | 1802 | 1 | 291 |
| Southwood, See Southood | |||||
| Southwood, Edward (Southood) | 23 | Opequon Creek | 1792 | 1 | 137 |
| Sparr, Theodorus | 46 | Adj. Francis Harvey | 1793 | 1 | 157 |
| Spaw, See Spear, Spoar | |||||
| Spaw, Uther (alias T. Spear) | 170 | Sleepy Creek | 1777 | 1 | 567 |
| Spear, Uther | 50 | Sleepy Creek | 1789 | 1 | 69 |
| Spear, Uther (alias T. Spear) | 170 | Sleepy Creek | 1777 | 1 | 567 |
| Spero, George (Sperow) | 8a1r24p | Wts. Opequon | 1815 | 1 | 375 |
| Spoar, Uther | 50 | Sleepy Creek | 1789 | 1 | 69 |
| Spoar, Uther | 170 | Sleepy Creek | 1777 | 1 | 567 |
| Standley, Isaac (Stanley) | 258 | Adj. Wm. Cochran | 1789 | 1 | 55 |
| Stephen, Robert | 2a3r | Adj. his own | 1794 | 1 | 164 |
| Stephen, Robert | 2,144 | Wts. Potomac | 1810 | 1 | 355 |
| Stephenson, Richard | 75 | Adj. D. Kennedy | 1794 | 1 | 168 |
| Stephenson, Richard et al | 309 | Tilhauzey's Branch | 1777 | 1 | 566 |
| Stillwell, William | 680 | Back Creek | 1856 | 2 | 289 |
| Stonebraker, Casper et al | 393a3r | Sleepy Creek | 1775 | 1 | 528 |
| Storm, Peter | 400 | Sleepy Creek | 1802 | 1 | 286 |
| Stout, Philip | 50 | Sleepy Creek | 1814 | 1 | 366 |
| Strider, Isaac | 23 | Wts. Potomac | 1777 | 1 | 565 |
| Strode, James | 122 | North Mountain | 1788 | 1 | 22 |
| Strode, James | 400 | Wts. Potomac | 1792 | 1 | 140 |
| Strode, James | 101 | North Mountain | 1780 | 2 | 544 |
| Strode, Jeremiah | 580 1/8 | Wts. Opequon | 1775 | 1 | 532 |
| Stuart, Robert | 42 | Back Creek | 1777 | 1 | 572 |
| Stuart, Robert | 28 | Tomahawk Run | 1772 | 1 | 486 |
| Surgeant, See Sargent, Searjeant | |||||
| Surgeant, Richard | 256 | Back Creek | 1790 | 1 | 92 |
| Swaim See Swim | |||||
| Swaim, Mathias et al | 346 | Sleepy Creek | 1788 | 1 | 10 |
| Swaim, Mathias Jr | 324 | Wts. Potomac | 1780 | 2 | 533 |
| Swaim, Mathias Jr. et al | 256 | Sleepy Creek | 1788 | 1 | 450 |
| Swaim, Mathias Sr. | 346 | Adj. Richard Riggs | 1780 | 2 | 557 |
| Swearinger, Thomas et al | 330 | Sleepy reek | 1804 | 1 | 472 |
| Swim See Swaim | |||||
| Swim, Mathias Jr. | 100 | Sleepy Creek | 1809 | 1 | 350 |
| Swim, Mathias Sr. | 200 | Sleepy Creek | 1809 | 1 | 351 |
| Swim, Mathias (the 3rd) | 100 | Sleepy Creek | 1797 | 1 | 204 |
| Swift, Godwin | 345 | Sleepy Creek | 1792 | 1 | 141 |
| Sylar - See Silar, Siler | |||||
| Sylar, Elizabeth | 3a2r22p | Stookey Spring Run | 1815 | 1 | 379 |